The terms ‘adjunctive’ and ‘multimodal’ therapy are often used interchangeably, which may cause confusion. It is imperative to understand the differences between these approaches in order to achieve treatment goals in spasticity management. Addition of a secondary pharmacologic or non-pharmacologic treatment to optimize the efficacy of the initial modality, is considered an adjunctive therapy. Multimodal therapy is an integrated, patient-centric program of pharmacologic and non pharmacologic strategies utilized in a concurrent/integrated or sequential manner to enhance the overall treatment effect across a variety of spasticity associated impairments. This paper aims to clarify the differences between adjunctive and multimodal therapies, provide a brief evidence-based review of such approaches, and highlight clinical insights on selecting multimodal and adjunctive therapies in spasticity management.